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Abstract In recent years, the incidence of colorectal cancer is still on the rise

Upon interaction with GSH, IR806-PDA is converted into IR806-S-NH, resulting in a spectral shift (from 680 to 820 nm) and generating ratiometric photoacoustic signals that correlate with GSH levels

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This underscores the decisive contribution of precise targeting to the ultimate therapeutic outcome

This leads us to pose whether NADPH or downstream protein/metabolites form the foundation of ferroptosis defence in disease

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