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Five bacterial phyla including Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Fusobacteria can participate in tryptophan metabolism, being those belonging to the Clostridium, Burkholderia, Streptomyces, Pseudomonas or Bacillus genera the most important modulators [209]

Transient irritability, possibly linked to phenol sensitivity, was the only notable adverse effect, suggesting a need for more tolerable formulations for pediatric use [261]

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