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Annu Rev Pharmacol Toxicol 2019;59:555575 [DOI] [PMC free article] [PubMed] [Google Scholar] 5

The effect of thiols (GSH, Cys, DTT) on the reduction of cytochrome c GSH is the thiol compound of largest concentration in the cells

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The percent of oxidized mito-Grx1-roGFP2 in U87vIII CHCHD2 KO cells was decreased by 15.8% compared to that measured in CHCHD2 WT cells, indicating that the pool of glutathione in the mitochondrial matrix of KO cells was more reduced than the WT counterparts (Fig