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Cystinosin-LKG, the alternatively spliced isoform of cystinosin, has a broader localization that could be leveraged to reduce cystine accumulation, restore lysosomal function, and lower apoptosis rates in cystinotic proximal tubule cells [155]

10.1080/15440478.2021.1994092 151 ParkJ

Key Points Individuals with GSTM1 -positive and GSTT1 -positive genotypes are at increased risk for renal cell carcinoma (RCC) when occupationally exposed to certain toxicants Individuals with the GSTM1 -null genotype are at increased risk for bladder cancer, which might be potentiated by smoking and occupational hazards Data on the influence of GSTT1 polymorphism on the risk for transitional cell carcinoma (TCC) are inconsistent In the process of kidney cancerization, expression of GSTA isoenzymes is downregulated, which contributes to decreased antioxidant capacity in RCC and might enhance RCC growth In the malignant phenotype of TCC of the urinary bladder, upregulation of GSTT1 and GSTP1 might provide a reduced cellular environment and inhibit apoptotic pathways, respectively

They used AlphaFold2 to predict the structure of the original sensor, removed the unstructured linker computationally, and reoriented Grx1 to align the GSSG binding site with the reactive cysteines of roGFP2

doi: 10.1007/s00702-022-02509-1 12

In contrast, under Gln-deprived conditions, miR-29b-3p expression was markedly upregulated, while c-Myc overexpression completely abrogated this upregulation effect (Fig