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Folate, vitamin B6, and vitamin B12 all play major roles in lowering homocysteine by converting it to methionine

Brain fog Headaches Fatigue Moodiness and irritability Bloating Diarrhea or constipation Joint pain Nausea Skin issues Flu-like symptoms You are more likely to experience die-off symptoms if your detox pathways are compromised (e.g., if you have an MTHFR mutation)

doi: 10.3389/fnut.2025.1581848 Received 23 February 2025 Accepted 22 September 2025 Published 15 October 2025 Volume 12 - 2025 Edited by Roberta Zupo, University of Bari Aldo Moro, Italy Reviewed by Padhmanand Sudhakar, Kumaraguru College of Technology, India Edem E

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