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Zinc together with Vit B2 and B6 act as three important co-enzymes in the production of energy or increased metabolism

2.3 Neuroinflammation Some studies have shown that berberine activates macrophages and increases their phagocytic function, increases the production of interleukin (IL)-1, and enhances non-specific immunity, can be used as a neuroprotective agent to prevent Alzheimers disease (Kumazawa et al., 1984

These differentially hydroxymethylated regions (DhMRs) were enriched with genes associated with neurogenesis and neuronal survival (Kumar et al., 2018), involving pathways such as Wnt / - catenin / Sox , NMDAR / calcium / CREB , and GABA type A receptor pathways

That takes randomized, controlled clinical trials