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Available diagnostic criteria Despite its high prevalence, there are still no universally accepted clinical criteria to characterise ME/CFS, making early and accurate diagnosis difficult (52)

In Arabidopsis, arGST loss-of-function mutations were additionally linked with an increased content of flavonols 19,45 , most probably due to a second oxidation of accumulating flavan-3,3,4-triol ( 4 ), which is catalysed by At LDOX in vitro 11,12,13