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Furthermore, the lack of cystathionine -synthase seemingly upregulates the expression of genes with regard to ER stress, hepatic lipid homeostasis, as well as genes linked to hepatic steatosis (57), whereas knockout of cystathionine -lyase results in decreased hepatic lipolysis (58)

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Studies have shown that elderly subjects treated with IGF-1 are better able to better preserve lean muscle mass [7, 8, 9]