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In PD specifically, curcumin has improved motor behavior and dopaminergic neuron survival in some rodent studies, and it continues to be investigated in preclinical and early clinical settings (such as trials of curcumin formulations or analogues with improved bioavailability) (80)

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However, the presence of ketone bodies in the urine suggests that, despite the low CoA, CoA-dependent FA degradation proceeds unimpeded (Fig