The reduction of c-Myc decreases the expression of GLS1, a key enzyme in Gln metabolism, resulting in impaired Gln utilization and increased sensitivity to chemotherapy in liver cancer (32)
[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Bowling A
Sequestrants in food
2037-A DIAGNOSTIC ACCURACY OF VCTE AND 2D-SWE IN BIOPSY-PROVEN NAFLD AND PERFORMANCE OF TWO-STEP APPROACHES TO PREDICT ADVANCED FIBROSIS Madalina-Gabriela Taru 1,2 , Dan-Corneliu Leucuta 2 , Lidia Neamti 2 , Anca Maniu 3 , Vlad Taru 4 , Bobe Petrushev 3 , Ioana Rusu 3 , Cristian Tefas 2,3 , Petra Fischer 2 , Andreea-Ioana Terec 5 , Lucia Maria Procopciuc 2 , Bogdan Procopet 2 , Horia Stefanescu 3 and Monica Lupsor-Platon 2,3 , (1)Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, Italy, (2)Luliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania, (3)Octavian Fodor Regional Institute of Gastroenterology and Hepatology, 400162 Cluj-Napoca, Romania, (4)Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, (5)Niculae Stncioiu Heart Institute, 400001, Cluj-Napoca, Romania Background: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) pose significant challenges to the healthcare system, and the prediction of advanced fibrosis (F3) is a crucial aspect in their management
Cellular membrane lipid oxidation can be induced by (1) exogenous physical and chemical inductors such as UV light, or ionization radiations, and (2) various endogenous enzymatic systems generating ROS
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