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Maintaining improvements long-term requires either continued use or transition to lifestyle interventions that sustain AMPK activation (resistance training, caloric cycling)

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Upon binding to this target, the compound is studied for its ability to initiate cellular signaling processes

Additional research by Stanley and colleagues showed that tesamorelin reduced hepatic (liver) fat by approximately 37% in individuals with fatty liver disease, making it one of the few compounds that addresses both visceral adiposity and its downstream consequence of liver fat accumulation

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