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Despite most autoantibodies associated with RA and CD being considered as non-specific, due to their ability to recognise multiple components, there have been reports of circulating antibodies which target TJs and neuronal structures as well as organs such as the pancreas, stomach, and liver in those diagnosed with the latter of these two conditions (Shaoul and Lerner 2007)

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western blot results indicated that Pep-B inhibited inflammatory activation mediated by the NF-B and MAPK pathways

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Thus, overcoming the immunosuppressive barriers within the TME remains critical for maximizing therapeutic outcomes