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Circulation 102:351356 [DOI] [PubMed] [Google Scholar] Villarino AV, Kanno Y, OShea JJ (2017) Mechanisms and consequences of JakSTAT signaling in the immune system

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After ingestion, folate from food is hydrolyzed in the gut, where it is converted first to tetrahydrofolate by the enzyme dihydrofolate reductase and then to the active form 5-MTHF, by the enzyme MTHFR