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Comprehensive natural products II

In the HD model, reduced expression and deacetylase activity of SIRT3, which in turn prevents the deacetylation of LKB1 and SOD2, leading to a decrease in the level of NAD + , defects in mitochondrial biogenesis and accumulation of ROS

doi: 10.1038/29795 288 DixitVDSchafferEMPyleRSCollinsGDSakthivelSKPalaniappanRet al

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When compounds were detected in both ion modes, the one with the highest signal-to-noise ratio was retained

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