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Evidence suggests that the pathogenic mechanism of prion protein/exosome transfer is activated in the extracellular space and across the NMJ synapses during the degeneration of the motor cortex with centrifugal spreading [201,202,203]

Vegetables: Spinach, broccoli, Brussels sprouts, and tomatoes contain modest amounts of ALA

hydrophilic compounds, as noted by Betageri et al

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To calculate the percentage inhibition, the differential signal activated by calcium in the presence of compounds was expressed in relationship to that observed in DMSO wells (100% activation) and to the GFPSTX7:FlagMunc13-4-C2A*B* mutant control (0% activation)