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Glyphosate upregulated pro-inflammatory cytokines (TNF- , IL-1, IL-6), increased TLR-4 and NOS2 expression, activated mitochondrial apoptosis by increasing pro-apoptotic proteins (BAX, CYTOCHROME C, and CASPASE-3) while decreasing anti-apoptotic BCL-2 protein levels, with corresponding changes in gene expression

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This section examines the specific roles of glutamine, tryptophan, and leucine in directing immune cell fate through interconnected metabolic and signaling pathways

AIMP3 upregulated p53 by directly interacting with the FAT domains of ataxia telangiectasia-mutated/ATM and Rad 3-related (ATM/ATR), thereby responding to DNA damage