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Hif-2alpha, but not hif-1alpha, promotes iron absorption in mice

It seems it has capabilities to help heal the body from virtually any acute or chronic injury

Turkalj EM, Vissers C

The use of the glycolysis inhibitor 2-DG has been shown to alleviate the pathological condition in mice by reducing lactate accumulation, suggesting that targeting glucose metabolism may be a potential strategy for treating PD [88]

240 Furthermore, the expression of enzymes in the NAD + salvage pathway, including Nmrk1, Nampt, and Nadk, has circadian oscillation patterns in WT and Liver-RE mice that exclusively express BMAL1 in the liver, suggesting the circadian clock might reprogram NAD + salvage synthesis to maintain the fluctuation of NAD +

Other targeted HK2 inhibitors include lonidamine (LND) [88], GEN-27 [89], and some natural compounds, such as resveratrol and astragalin [90, 91]