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Most patients undergo surgery combined with adjuvant and/or neoadjuvant chemotherapy, depending on the stage of the disease, followed by a long course of SERM if the cancer cells express hormonal receptors

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Interestingly, direct fibroblast proliferation as measured by cell assay was not significantly affected, suggesting the mechanism is more nuanced than simple cell replication

Under these conditions, the copper-peptide complex remains stable and active

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In a similar set of preclinical studies, genistein sensitized the diffuse large cell lymphoma subtype of non-Hodgkin lymphoma to the standard chemotherapeutic combination for this disease (cyclophosphamide, doxorubicin, vincristine, and prednisone), increasing the antitumor effect of the chemotherapy (Mohammad 2003)