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Peripheral neuropathy frequently present in untreated patients with diabetes or other glucose dysregulating syndromes (i.e., impaired glucose tolerance and metabolic syndrome), sarcoidosis, thyroid dysfunction, vitamin B12 deficiency, and Gulf war illness have overlapping symptoms with CFS and fibromyalgia (Hovaguimian and Gibbons 2011

Unlike fatty acid metabolism, which is primarily controlled by SREBP-1c, cholesterol homeostasis is governed by SREBP2, a transcription factor that senses intracellular cholesterol levels and modulates cholesterol synthesis, uptake, and storage accordingly [50]

If tremors exist or body movement is greatly affected, a referral may be given to a neurologist to rule out neurodegenerative diseases such as Parkinson's Disease

ASCT, in combination with high-dose chemotherapy (usually melphalan), is a treatment that, for many eligible myeloma patients, offers a very good chance for a long-lasting response

Similarly, PTC Therapeutics leveraged a splicing-focused drug discovery platform to develop compounds mimicking branaplams mechanism

2016 May;31(5):706-13