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Still beyond the 28-day window, but the loss is smaller

314,315 Given the close correlation between diet-induced impairment in insulin sensitivity and body weight gain, a notable increase in PGE2 levels and activation of its receptor EP4 in the mediobasal hypothalamus during HFD feeding is evident

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Apr 2004;63(4):450-2.doi:10.1136/ard.2003.011502

Chronic alcohol use can by itself damage the intestinal barrier and increases plasma LPS levels, both of which normalized after a longer period of abstinence (145, 148)