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J.O'TooleP

Overall, the level of heterogeneity was modest for most loci

PLoS One 14 (12), e0225931

If it does not, consider lowering or discontinuing the dose

Clinical studies demonstrate that berberine supports healthy lipid metabolism and cholesterol homeostasis.*1-6 Berberine can activate an important metabolic enzyme known as adenosine monophosphate-activated protein kinase (AMPK), a central regulator of cellular energy homeostasis.* Mechanistic research in vitro and in vivo suggests that berberine can decrease cholesterol and triglyceride synthesis by activating AMPK.7-9