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Early-phase human trials are small, well-controlled studies centered on safety, reproductive hormones, and surrogate markers such as ovarian reserve tests and sperm parameters ahead of any efficacy trials

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In rat models of autoimmune thyroiditis, ginsenosides have demonstrated efficacy in reducing thyroid autoantibody titers by modulating cytokine expression and promoting a balanced Th1/Th2 ratio (Chen et al

At sub-antimicrobial doses, these medications act primarily through anti-inflammatory pathways

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