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Kangas et al

Science 312 , 16501653 (2006)

(66), the mechanism of sinomenine inhibiting arthritis in CIA rats may be related to regulating the frequency of Treg and Th17 cells in intestinal lymph nodes and transporting lymphocytes (especially Treg cells) from the intestine to the joints

doi:10.1002/bmc.1382

As the first ingredient after water, it plays a major role in the formula, helping to even tone, refine the look of pores, and support the skin barrier so everything else works more efficiently