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Besides that, the decrease was more remarkable in the regression group at 52 weeks of treatment (the median difference in CHI3L1 levels: -19.09 ng/ml vs

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This generates superoxide (O2 - ) and hydroxyl (OH - ) radicals by inhibiting bacterial DNA gyrase and promoting the Fenton reaction, thereby increasing mutagenesis 4

This coenzyme is principally re-generated by a group of NADP-dehydrogenases enzymes including glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH), both belonging to the pentose phosphate pathway, the NADP-malic enzyme (NADP-ME), and NADP-isocitrate dehydrogenase (NADP-ICDH)

doi: 10.1016/j.rbmo.2018.12.025 42 MauryaVKSzwarcMMFernandez-ValdiviaRLonardDMYongSJoshiNet al