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You can have a low TSH with symptoms of hypothyroidism if your cells aren't receiving adequate thyroid hormone, which may require switching from T4-only medications to combinations containing T3

Basically, thyroid hormones heavily impact important aspects of normal bodily functions, including liver detoxification, metabolism & body weight, muscle strength, menstrual cycles, cholesterol levels, heart-rate & breathing, sexual function, central and peripheral nervous systems, and even mood

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Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess