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The following have been previously described: vps29 20 , snx1 51 , snx2a 51 , snx2b 51 , vps9a 57 , mon1-2 45 , ccz1a 58 , ccz1b 58 , vps35a-1b-2c-1 7 , vps35b-1c-1 7 , GFP-VSR1 59 , VPS29-GFP 20 , SNX1-GFP/Ch 8 , mRFP-SYP32 (WAVE22) 60 , Ch-RAB5 (WAVE7) 60 , Ch-RAB7 (WAVE5) 60 , VHA-a1-mRFP 61 , mCIT-PH OSBP (P7Y) 62

These disorders are characterized by mtDNA mutations that impair mitochondria electron transport chain enzyme complexes, which can result in increased ROS production, oxidative damage, and decreased ATP production (Quintana et al., 2010