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4.3 Targeted therapeutic strategies in response to ERS It is well known that both the morphology of biomaterials and the UPR pathway can significantly affect the osteogenic differentiation of stem cells and controlling UPR-mediated osteogenic effects by modulating the surface morphology of biomaterials is expected to be an emerging therapeutic strategy (189, 190) ( Figure 2 )

Assumptions were made about the involvement of encephalitis [17, 18] and medications used in the treatment protocol of COVID-19 such as steroids, chloroquine derivatives, and benzodiazepines [19]

Working with human hair follicles kept alive in the laboratory and with cultured dermal papilla cells, the cells at the base of the follicle that drive its growth, the authors reported that very low concentrations of AHK-Cu lengthened the follicles and encouraged the dermal papilla cells to multiply

Some PD-related symptoms, such as gait disorders, including stride variability, freezing of gait, balance problems, and postural instability, have been reported in the literature