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PAL catalyzes the non-oxidative deamination of phenylalanine to trans -cinnamic acid, which is the fundamental building block for polyphenol synthesis in the phenylpropanoid pathway (Ertani et al., 2016)

Xia L, Cregan A G, Berben L A, Brasch N E, Studies on the formation of glutathionylcobalamin: any free intracellular aquacobalamin is likely to be rapidly and irreversibly converted to glutathionylcobalamin, Inorganic Chemistry

Oxid Med Cell Longev 2020

doi: 10.1212/01.wnl.0000183063.99107.5c

doi: 10.1091/mbc.E18-08-0515 37 WuX.TuB

Although PyroGlu is not routinely available in clinical laboratories, this study presents data that supports its usefulness, though more work is needed before being used in clinical practice