This defect leads to intracellular copper accumulation, exacerbating local oxidative stress and promoting aneurysm progression

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Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: translational difficulties and pitfalls
Intravenous NR or NMN administration in mice results in rapid conversion into circulating NAM and NAD + boosting in liver, kidney, skeletal muscle, while NAD + in these organs after oral administration increases to a lower magnitude 39,69
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