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doi:10.1021/acs.bioconjchem.4c00545

Immune cells can directly manipulate the synthesis and catabolism of the basic components of the ECM, or they may indirectly regulate the ECM through the secretion of cytokines

Alatzoglou KS, Turton JP, Kelberman D, Clayton PE, Mehta A, Buchanan C, Aylwin S, Crowne EC, Christesen HT, Hertel NT, Trainer PJ, Savage MO, Raza J, Banerjee K, Sinha SK, Ten S, Mushtaq T, Brauner R, Cheetham TD, Hindmarsh PC, Mullis PE, Dattani MT

Research-use status: Cagrilintide is sold by research peptide suppliers as a lyophilized powder for in-vitro and laboratory research only

This type of supplier is important for cosmetic manufacturers, formulators, and skincare brands developing their own GHK-Cu formulas

Detailed biophysical studies (X-ray crystallography, EPR, NMR) elucidated that in GHK-Cu, the Cu(II) ion is coordinated by the imidazole side chain nitrogen of histidine, the alpha-amino nitrogen of glycine, and the deprotonated amide nitrogen of the glycine-histidine bond