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(2013) studied serum from 22 FM patients compared with 22 healthy female controls and identified significant alterations in purine metabolism, specifically decreased levels of adenosine, a precursor for ATP synthesis

The FRAP method is based on the reduction of complexes of 2,4,6-tripyridyl-s-triazine (TPTZ) with ferric chloride hexahydrate (FeCl36H2O)

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HK2 deficiency impaired glucose dependent ribonucleotide synthesis via the nonoxidative PPP while maintaining NADPH production by the oxidative PPP, suggesting that the elevated nonoxidative PPP in K-Ras-dependent cancer is also mediated by the increased expression of HK2 47

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