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These PUFAs are subsequently esterified into phospholipids by lysophosphatidylcholine acyltransferase 3 (LPCAT3), generating PUFA-phospholipids (PUFA-PLs) that are highly susceptible to oxidation by lipoxygenases (ALOXs), ultimately leading to ferroptosis (109, 110)

As neutrophils are able to efferocytose apoptotic cells during inflammation [86], SELENOF might contribute to the regulation of neutrophil function and its communication with neighboring cells in the immune microenvironment

10.1161/ATVBAHA.115.305235 139

Comparative genome analysis of a Saccharomyces cerevisiae wine strain

BarileEditor M

Furthermore, curcumin has been shown to inhibit the activity of key enzymes involved in prostaglandin and leukotriene synthesis, specifically cyclooxygenase-2 (COX-2) and lipoxygenase (LOX), both of which are often overexpressed in inflammatory and cancerous conditions and contribute to tumor growth and survival