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It also plays a role in improving cellular metabolism and providing antioxidant support

These biomarkers are also used to track the efficacy of antioxidant therapies, with decreasing levels of MDA and 4-HNE indicating effective intervention [35]

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Rats with type 2 diabetes treated with mulberry leaf extract (containing CGA), rutin, or isoquercitrin showed that the extract and pure CGA effectively lowered blood glucose, whereas isoquercitrin had minimal effect, indicating CGA and rutin as the active compounds [152]

3.8 Caspase-3 Under both normal and low-temperature conditions, apoptotic factors such as caspase-3 are activated during hindlimb unloading-induced atrophy, accompanied by DNA fragmentation and lipid peroxidation