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Conversely, when oxidative challenges exceed physiological levels, they can disrupt redox signaling and cause oxidative damage to biomolecules, termed oxidative distress

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doi: 10.1155/2017/3908061 129

Uncoupling proteins and the control of mitochondrial reactive oxygen species production

4.2.4 Donor cell developmental stage Although fetal cells remain the most established donor source in the field, factors such as their topographic origin, developmental stage, and biological sex, must be carefully considered, as each can significantly influence how the transplanted neurons integrate into the host environment