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The observed increase in mitochondrial malate and cytosolic 2-oxoglutarate through elevated SLC25A11 expression aligns with the systemic energetic dysregulation and oxidative stress reported in plasma metabolomic studies in ME/CFS patients

Moreover, blending the extracts with the known anticancer drug 5-fluoruoracil boosted cell cytotoxicity

This powerful effect was particularly important during the peak outbreak of COVID-19 where it was suggested as a possible supplement to help suppress the widespread inflammation often leading to organ failure

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This waning of efficacy is also observed for booster vaccination when Omicron is the dominant circulating variant, with Menegale et al