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In theory, the difference in the effects might be attributed to a limited set of upstream and downstream effector proteins in erythrocytes compared with nucleated cells [84]

10.1016/S0735-1097(99)00216-8 [DOI] [PubMed] [Google Scholar] 219.Scharfstein JS, Keaney JF, Jr., Slivka A, Welch GN, Vita JA, Stamler JS, et al

Morgan AS, Sanderson PE, Borch RF, Tew KD, Niktsu Y, Takayana T, VonHoff DD, Izbicka E, Mangold G, Paul C, Broberg U, Mannervik B, Henner DW and Kauvar LM

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Moreover, IGF-1 signaling, which is implicated in neurodegeneration, modulates astrocytic redox balance by modifying mitochondrial activity 82

471 Ang II signaling pathways become activated with age and contribute to developing AS and vascular senescence