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The clinical signs and symptoms of cobalamin-related remethylation disorders may vary considerably and affect multiple organ systems, most prominently the nervous system and the bone marrow

PMID 9250994

Preoperative radiomics models using CT and MRI for microsatellite instability in colorectal cancer: a systematic review and meta-analysis

doi: 10.1074/jbc.R800046200 13 ShindouHHishikawaDHarayamaTYukiKShimizuT

Some disorders of intracellular cobalamin metabolism (cblC, cblD-MMA/Hcy, cblF, and cblJ) do not only compromise the synthesis of methylcobalamin, but also the synthesis of adenosylcobalamin, cofactor of the enzyme methylmalonyl-CoA mutase, leading to elevated concentrations of both tHcy and methylmalonic acid (MMA)

Something I learned from world-class high jumpers and pole vaulters, when they miss a bar, they have three attempts, and youll see them going to their journal or their coach between attempts, and theyll write down what is the thing Im going to take to the next attempt