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For a geared bicycle, efficency (input to output ratio) seems to be more or less the only constraint

doi: 10.1038/nrn2372 31 Marques-DeakACizzaGSternbergE

With particular emphasis on the toxicity induced by MeHg, it is known that its mercury atom directly interacts with the thiol group of GSH, leading to the formation of an excretable GS-HgCH 3 complex (Ballatori and Clarkson, 1982)

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Emerging evidence suggests that dietary modifications may serve as a viable strategy to ameliorate metabolic and reproductive dysfunction in PCOS (92)