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In SETD1B knockout cells, CHAC1 is not upregulated, preventing GSH depletion and conferring resistance to mycolactone-induced cytotoxicity (Figure 2) ( 3.6 Non-coding RNAs Non-coding RNAs (ncRNAs), encompassing long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play crucial roles in gene regulation without being translated into proteins