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The British National Formulary (BNF), for example, differentiates the prescription of hydroxocobalamin according to presenting symptoms, eg, For neurological involvement, it is advised to administer hydroxocobalamin by intramuscular injection, initially 1 mg once daily on alternate days until no further improvement, then 1 mg every 2 months. In the Netherlands, pharmacotherapeutic guidelines 51 recommend (for the same neurological symptoms or abnormalities) administration of 1000 mcg once or twice weekly for up to two years

Very rarely, individuals might have an allergic reaction symptoms would include hives, difficulty breathing, or swelling of the face and throat

Beyond BBB penetration, the selection of DDS in AD should also consider disease-specific pathological features that may affect therapeutic access and efficacy

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Results can be seen from the first injection It is not necessary to inject several cycles to see results

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