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1d was driven by bioisosteric replacement of the fragments bound to subpockets A-C, scaffold-hopping, de novo design, and medicinal chemistry and was facilitated by SZMAP/GamePlan 37 , vBrood 38 , and MOE software 39

Therefore the degraded keratin can potentially apply in the glutathione synthesis platform to upcycle this resource

4.9 Environmental obesogens and their impact on adipogenic regulation Environmental obesogens represent endocrine-disrupting chemicals that promote obesity through alterations in adipogenesis and metabolic homeostasis (218, 219)