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How are hydrogen peroxide messages relayed to affect cell signalling

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Energy metabolism disorders in the development of diseases Energy metabolism in neurodegenerative diseases Neurodegenerative diseases such as Alzheimers disease (AD) and Parkinsons disease (PD) are frequently linked to abnormal changes in energy metabolism and oxidative damage during their progression

Cheng C, Hu J, Li Y, Ji Y, Lian Z, Au R, et al

Knight RA, Scarabelli TM, Stephanou A

214 Under physiological conditions, increased Ca 2+ levels within mitochondria activate OXPHOS, stimulating ATP synthesis, inducing depolarization of the mitochondrial membrane, enhancing cellular respiration, activating Ca 2+ -dependent mitochondrial enzymes, and subsequently facilitating energy accumulation within mitochondria