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Popova, L

A proof-of-concept trial investigating metformin as an add-on treatment for mild or moderate SLE demonstrated that metformin down-regulated the NETs mtDNA-PDC-IFN pathway, leading to clinical improvement of SLE and reduced its reliance on prednisolone (133)

Imaging mild cognitive impairment and dementia in Parkinsons disease

For p H titration assays 34 , different buffers with a p H from 2.0 to 10.0 were prepared at a normality of 0.1

Biochem Pharmacol 47:2147-2156 Welch KD, Reilly TP, Bourdi M, Hays T, Pise-Masison CA, Radonovich MF, Brady JN, Dix DJ, Pohl LR (2006) Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice

Data from cohorts of children with ASD indicate that up to 80% exhibit biomarkers of mitochondrial dysfunction , particularly within Complex I and IV of the electron transport chain (ETC) [3, 4]