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Most online discussions mention different approaches, but there is no universal standard

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On top of that, low B12 contributes to high homocysteine levels

For this reason cobalamin is the term used to refer to compounds having vitamin B 12 activity

Vitamin B12 can decrease blood homocysteine, a type of amino acid that is associated with an increased risk of heart disease

Dave Asprey, founder of Bulletproof and a prominent biohacker, has discussed 5-Amino-1MQ in combination with other peptides, highlighting "a lot of buzz about this peptide especially in combination with the 5-amino 1MQ."[28] He suggests it for biohackers seeking metabolic hacks without extreme diets