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Collectively, these findings allow us to exclude significant toxicity risks associated with macrophage-mediated drug delivery in tumor therapy

doi: 10.1172/jci.insight.95676 83 DimikMAbeysinghePLoganJMitchellM

Cyclopamine disrupts tumor extracellular matrix and improves the distribution and efficacy of nanotherapeutics in pancreatic cancer

Once activated, these receptors initiate intracellular signaling cascades , such as the PI3K-Akt pathway, which are critical for muscle protein synthesis, cellular growth, and survival (Jones & Clemmons, Endocrine Reviews )