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Further, in cytosol, they also maintain the stability of protein kinase B (AKT), a key regulator of cell survival (Koren et al., 2010)

As in T2D, APD-induced increases in circulating insulin are hypothesized to desensitize insulin-sensitive peripheral targets (e.g., liver, skeletal muscle, adipose tissue) over time, resulting in insulin resistance and weight gain 3,4,15