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HCMV infections usually progress subclinically in healthy adults, but cause morbidity and mortality in individuals with immature, impaired or senescent immunity, such as congenitally infected newborns, AIDS patients, transplant recipients and the elderly (Griffiths & Reeves, 2021)

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From earlier work focused on muscular dystrophy conducted with former Penn Dental Medicine faculty member Elizabeth Barton, now at the University of Florida, the researchers believed that a particular form of IGF, a precursor of the protein that includes a separate component known as an e-peptide, was likely to stimulate regeneration better than mature IGF-1 that lacked the peptide

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