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The active site residue C497S hTrxR1 is sandwiched between Ser415 hTrxR1 and Ser111 hTrxR1 , the latter being in hydrogen bond distance (3.6 ) to His108 hTrxR1 (Fig

However, to further improve therapeutic efficacy and safety and promote their clinical application, the performance of nanomaterials still needs to be optimized