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The maintenance of homeostasis is also contingent upon the equilibrium between matrix metalloproteinases and tissue inhibitors of metalloproteinases (Romualdo et al

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J Agric Food Chem 64:71047113 Peris-Daz MD, Guran R, Zitka O, Adam V, Krel A (2020) Metal- and affinity-specific dual labeling of cysteine-rich proteins for identification of metal-binding sites

This applies to both compounds, but it is especially critical for tirzepatide where dose escalation directly impacts GI tolerability