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Hypoxia also induces cellular adaptations which can hinder the efficacy of chemotherapy, such as reduced cellular uptake of drugs due to increased cellular acidity and drug efflux pump expression [82], whilst some chemotherapeutic agents require oxygen in order to facilitate their cytotoxicity [24]

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They were randomly assigned in the ratio of 1:1:1 to once-weekly subcutaneous CagriSema (n=31), semaglutide (n=31), or cagrilintide (n=30) (all escalated to 24 mg)